but the mechanisms regulating PDC activity—especially through post-translational modifications like acetylation—remain poorly understood. While previous research has focused on the ...

SLC25A1 drives citrate export from the mitochondria to the cytosol, where it fuels acetyl-CoA synthesis by ATP citrate lyase (ACLY). This acetyl-CoA supply sustains FSP1 acetylation and prevents its ...

Background: Augmented fatty acid oxidation (FAO) adversely affects cardiac function in diabetic patients. Mitochondrial protein lysine (K) acetylation is a critical mechanism modifying metabolic flux, ...

These enzymes can acetylate small molecules, metabolites, peptides, and proteins. This review presents current knowledge of acetylation mechanisms and functional implications in bacterial metabolism, ...

A zebrafish disease model of NAA60 deficiency displayed a motor deficit with altered phosphate homeostasis.This study establishes NAA60 as a causal gene for PFBC, provides a biochemical explanation of ...

the researchers discovered that the sites where CREB interacted with DNA to promote gene expression require prior acetylation mediated by CBP. "These findings not only elucidate the mechanism ...

Find more information on the Altmetric Attention Score and how the score is calculated. The impact of Lys28 acetylation on Alzheimer’s Aβ peptide binding to the lipid bilayer has not been previously ...

Strikingly, they show that FolSpv1 translocates SlPR1 from the apoplast back into the nucleus of tomato cells, suggesting a previously unknown mechanism employed by pathogenic microbes ... the ...

Myocardial infarction (MI) is accompanied by severe energy deprivation and extensive epigenetic changes. However, how energy metabolism and chromatin modifications are interlinked during MI and heart ...