在这项研究中，作者对来自30名志愿者（包括18名胃癌患者和12名健康个体）的238个胃腺体进行了全基因组测序。胃腺体是胃上皮的基本单位，每个腺体通常由一个干细胞的后代细胞组成，会形成单克隆细胞群。他们发现正常胃腺体细胞每年大约会积累27.8个单核苷酸 ...

Nuvectis Pharma, Inc. ("Nuvectis”, "Company”), a biopharmaceutical company focused on the development of innovative precision ...

研究人员针对 ARID1A 缺陷型卵巢透明细胞癌（OCCC）治疗难题，研究靶向 USP8，发现其可诱导合成致死，有望用于精准治疗。

Nuvectis Pharma, Inc.’s NVCT share price has surged by 12.68%, which has investors questioning if this is right time to sell.

First-in-class oral selective SMARCA2 (BRM) inhibitor FHD-909 (LY4050784) continues enrollment in Phase 1 trial for SMARCA4 (BRG1) mutated ...

Additionally, Nuvectis’ second asset, NXP800, a GCN2 activator, is in Phase 1b trials targeting ARID1a-mutated ovarian cancer. Although previous dosing regimens required adjustments due to ...

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Condition: Advanced Solid Tumor, Diffuse Large B Cell Lymphoma, Lymphoma, T-Cell, Mesothelioma, Malignant, Prostatic Neoplasms, Castration-Resistant, Endometrial ...

NXP800 Phase 1b study in patients with platinum resistant, ARID1a-mutated ovarian cancer is ongoing; Orphan Drug Designation granted by the U.S. FDA. Updated Phase 1b results anticipated in Q2 2025 ...

The researchers also looked for associations between outcomes and several biomarkers — including mismatch repair (MMR) protein, ARID1A, p53, PD-1, PD-L1, and combined PD-1/PD-L1. They found that ...