Just two months after its last pipeline company launch, Cambrian BioPharma unveiled another. Tuesday morning, the longevity biotech announced the debut of Amplifier Therapeutics, which is focused on ...

Adenosine monophosphate-activated protein kinase (AMPK) is a significant energy sensor in the maintenance of cellular energy homeostasis. Autophagy is a highly conserved catabolic process that ...

1Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China. 2Institute of Otolaryngology Head and Neck Surgery, Affiliated ...

Mammalian target of rapamycin (mTOR) and adenosine-monophosphate activated-protein kinase (AMPK) are major negative and positive regulators of autophagy, respectively. In cisplatin-induced acute ...

Western blot analysis was utilized to evaluate autophagy regulatory activity of the mammalian target of rapamycin (mTOR) through p70 S6 kinase1 (S6K1) and AMP activated protein kinase (AMPK) and its ...

AMPK, a highly conserved sensor of cellular energy status, is found in all eukaryotic cells and maintains metabolic homeostasis by reprogramming growth, metabolism, and autophagy in the face of ...

AMPKα knockout cells exhibit suboptimal autophagy induction in response ... and to the rest proteins at 1:1,000 dilutions for western blot. AMPK immunoprecipitation was performed using 1 ...

Decreased ULK1 phosphorylation by mTORC1 at S757 and activation of AMPK to phosphorylate ULK1 at S317 in response to nitrosative stress resulted in increased autophagy: the LC3-II/LC3-I ratio ...

one of the primary negative regulators of autophagy, functions, in part, by phosphorylating and inhibiting ULK1. In contrast, AMPK is a positive regulator that stimulates autophagy in response to ...

one of the primary negative regulators of autophagy, functions, in part, by phosphorylating and inhibiting ULK1. In contrast, AMPK is a positive regulator that stimulates autophagy in response to ...