During the process of selective autophagy, the autophagic machinery is targeted to specific cargos via selective autophagy receptors independent of the energy sensing pathways mTORC1 and AMPK.

Results: Morphological damage was observed in sciatic nerve samples from diabetic animals, accompanied by decreased p-AMPK expression and increased LC-3 levels. Notably, metformin ameliorated the ...

Dr. Weickert will present Pacylex at the OBIO® Investment Summit and Early Technology Showcase February 5-7, 2025, at the Arcadian Court & Loft, Toronto Mr. Kamdar will present Pacylex at the PWMC ...

Get Instant Summarized Text (Gist) Autophagy, particularly through the protein ATG5, plays a crucial role in maintaining brain health by regulating glucose metabolism in neurons. In Purkinje cells ...

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, Colorado 80045, ...

This important study provides solid evidence to support the anti-tumor potential of citalopram, originally an anti-depression drug, in hepatocellular carcinoma (HCC). In addition to their previous ...