AMPK会抑制mTOR，从而启动自噬。 此外，ATG家族基因（Autophagy-related genes）在自噬过程中也起到了关键的信号传导作用，许多自噬相关的遗传变异会 ...

Aging involves gradual functional decline across various biological systems, including impaired cellular mechanisms such as autophagy. Autophagy is responsible for degrading and clearing damaged ...

Figure 2. Entosis is induced by long-term starvation. (A) Short-term starvation for glucose induces AMPK-dependent autophagy and nutrient recycling (left). Long-term glucose starvation induces ...

Longevity-promoting regimens, including caloric restriction and inhibition of TOR with rapamycin, resveratrol or the natural polyamine spermidine, have been associated with autophagy (a ...

AMPK is associated with many anti-aging-related cellular processes, such as proteostasis, mitochondrial biogenesis, autophagy, mitohormesis, inflammation, and neurodegeneration. Therefore ...