AML是最常见的成人白血病类型之一，FLT3-ITD是最常见FLT3突变类型。3期试验中，与化疗相比，quizartinib方案将死亡风险降低22.4%，有潜力改变新诊FLT3-ITD ...

为探讨 AML 非强化治疗中出现可靶向克隆时的策略、MRD 检测应用等问题，研究人员分析相关疗法及生存数据。发现 Ven-Aza 序贯治疗或三联疗法可优化方案，MRD 检测仍需完善，AML 生存率显著提升。研究为临床提供方向。 急性髓系白血病（acute myeloid leukemia ...

2021年2月，Xospata(适加坦，吉瑞替尼)获国家药监局批准，治疗FLT3突变急性髓系白血病（AML）。 2021年03月31日讯 /生物谷BIOON ...

Panelists highlight that menin inhibitors represent a breakthrough in the treatment of KMT2A-rearranged AML by targeting the disease’s core epigenetic drivers, with early clinical trials like ...

Many mutations that contribute to the pathogenesis of acute myeloid leukemia (AML) are undefined. The relationships between patterns of mutations and epigenetic phenotypes are not yet clear.

5月21日，中国科学院上海营养与健康研究所王兰研究组在国际学术期刊Developmental Cell在线发表题为“SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis”的研究论文 5月21日，中国科学院上海营养与健康研究所王兰研究组在国际学术期刊Developmental Cell ...

Panelists explain that KMT2A-rearranged acute myeloid leukemia (AML) is an aggressive, molecularly distinct leukemia subtype marked by menin-dependent transcriptional dysregulation, poor response to ...

Understanding the fundamental molecular mechanisms underlying normal hematopoiesis and AML pathogenesis can aid the development of novel and effective targeted therapies. Prof. Wang concludes by ...

it is above all the perturbation of the RUNX1 gene -- a gene that regulates many other genes -- that seems to be responsible for AML pathogenesis. Targeting the perturbed regulator could pave the ...

Understanding the fundamental molecular mechanisms underlying normal hematopoiesis and AML pathogenesis can aid the development of novel and effective targeted therapies. Prof. Wang concludes by ...

while gaining an understanding of the functional characterization of AML pathogenesis. "AML is the most common type of leukemia in adults, yet the challenging nature of the disease means the 5-year ...