The yeast nuclear endonuclease Rnt1 has a well-characterized role in the maturation of many ncRNA precursors. However, the scope and consequence of its function in mRNA degradation pathways is much ...

Important molecular machines in the cell, such as ribosomes and splicesomes, are RNA-based. Biological RNA molecules rely on long-range, tertiary interactions to initiate, guide, and stabilize the ...

Moreover, the correlation between the structure of chromatin and various factors such as transcriptional repressor CTCF binding sites, replication timing and many epigenetic features has been ...

The RNP complex is the influenza virus’s essential package, the virus’s blueprints and a copy machine all rolled in one. The ...

and the Hebrew University of Jerusalem have developed a streamlined process that predicts the structure of an RNA molecule down to the atomic level. Members of the research community can come to ...

Cells use biomolecular condensates to organize biochemical reactions without membranes, but how these structures form and dissolve remains poorly understood. In early Caenorhabditis elegans embryos, P ...

It squeezes into such a tight space by folding into a protein-rich structure called chromatin. This structure is thought to vary between ... On the other hand, knots would prevent the genome from ...

When RNA molecules are synthesized by cells — a critical process in the creation of proteins and other cellular functions — they typically undergo a series of “folding” events that determine their ...

Abstract: Accurate prediction of RNA secondary structures including pseudoknots is crucial for understanding RNA bio-logical functions. However, traditional methods for predicting RNA secondary ...

Hoping to gain more insights into their biological functions, the research team decided to analyze the 3D structures of the RNA molecules. They took their samples to SLAC, where they used ...

But Yale researchers have now developed a method to map and measure the structure of RNA as it develops, an advance that may help scientists design more effective treatments for a host of diseases.