Our results provide new insight into the molecular mechanisms of the DNA homology search and strand-exchange processes. In this study, we carried out cryo-EM analyses of human RAD51 in different ...

The world’s most famous molecule – the DNA double helix – sometimes doubles up again. Researchers have now found this quadruple-stranded form in healthy human cells for the first time.

Researchers have revealed the structural mechanisms of a major DNA repair pathway in human cells ... It is essential for repairing double-stranded breaks in DNA and for DNA crossover events ...

On their own, however, polymerases aren't good at staying on the DNA strand. They require CTF18-RFC in humans and Ctf18-RFC in yeast to thread a ring-shaped clamp onto the DNA leading strand ...

Not all DNA looks like the familiar twisted ladder. Sometimes, parts of our genetic code fold into unusual shapes. One such ...