Aspartyl beta-hydroxylase is an alpha-ketoglutarate-dependent dioxygenase that hydroxylates aspartate and asparagine residues in EGF-like domains of ... 11:1319–1326. CAS PubMed ...

Ordinarily, 17-OHP is an excellent substrate for CYP21A2, yielding 11-deoxycortisol, and 11β-hydroxylase (CYP11B1) catalyzes the final oxygenation reaction to yield cortisol.

Yes, I do think we need non-glucocorticoid forms of therapy to treat 21-hydroxylase deficiency congenital adrenal hyperplasia.The most common form of congenital adrenal hyperplasia (CAH) is a ...

Men with classic 21-hydroxylase deficiency are at risk for infertility. 1 The mechanisms are complex and involve three factors: gonadotropin inhibition due to the excessive secretion of progestin ...

Will Prolyl Hydroxylase Inhibitors Supplant Erythropoiesis-Stimulating Agents and IV Iron in the Treatment of Chemotherapy-Induced Anemia?. JCO 43 , 118-121 (2025). DOI: 10.1200/JCO-24-01694 ...

Background: Abiraterone acetate (Ab) is an oral inhibitor of 17 alpha hydroxylase and C17,20-Lyase, which are important in adrenal androgen synthesis. A phase I study was undertaken to define the ...