它们的精准迁移至关重要，而这一过程离不开趋化因子受体 CXCR4 和鞘氨醇 - 1 - 磷酸受体 1（S1P 1 ）的参与。CXCR4 如同 “导航仪”，引导造血干细胞和免疫细胞归巢；S1P 1 则像 “开关”，控制着免疫细胞从淋巴器官的释放。然而，这两个 “关键角色” 之间的 ...

Type 1 diabetes occurs when the immune system attacks pancreatic beta cells. Type 2 diabetes happens when the body cannot use insulin effectively. The two types differ in symptoms, causes ...

The bicyclam AMD3100 is a well-known small molecule CXCR4 antagonist that strongly and specifically inhibits X4 HIV-1 infection. Tetrahydroquinoline-based AMD070 is a potent and specific X4 HIV-1 ...

Following up on this discovery, the researchers investigated whether CXCL12 is involved in the recruitment of CD8+ cells by blocking the corresponding receptor (CXCR4) for this signaling protein ...

Get Instant Summarized Text (Gist) Approximately 10% of South Asian immigrants aged 45 and older in Canada have hypothyroidism, with a 77% higher likelihood compared to Canadian-born individuals ...

Body Dimensions 145 x 70.4 x 8.6 mm (5.71 x 2.77 x 0.34 in) ...

例如在乳腺癌细胞系的研究中，它可以减少癌细胞向肺部的转移 。 HIV 研究：CXCR4 也是 HIV-1 进入宿主细胞的共受体之一 。有研究探索利用 CTTHWGFTLC, CYCLIC TFA 阻断 CXCR4 来抑制 HIV-1 感染的可能性 。虽然目前还处于基础研究阶段，但为艾滋病的治疗提供了新的思路 ...

Rd 4 pick 128: Antwaun Powell-Ryland, Edge Rusher, Virginia Tech An undersized edge rusher (6-2 1/4, 253), Powell-Ryland could drop in the draft because of his average size and short arms (31 1/8 ...

该研究聚焦三阴性乳腺癌（TNBC）免疫治疗难题，发现抑制趋化因子受体 4（CXCR4）联合抗程序性死亡受体 1（anti-PD-1）治疗可显著提升 TNBC 免疫治疗效果，为 TNBC 免疫治疗开辟了新方向，有望改善患者预后，推动 TNBC 临床治疗的发展。 一、研究背景 TNBC 是一种 ...

Cells were pretreated with 20 μg/ml antibody against CXCR4 (30 min at room temperature; PharMingen, San Diego, California), 100 ng/ml pertussis toxin (30 min at 37 °C), 1 μg/ml genistein (20 ...

CXCR4 mRNA expression increased with the degree of hearing loss when compared with ... Halliday et al. proposed a genetic severity score (1, tissue mosaic; 2A, mild classic; 2B, moderate classic; and ...