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ADC药物研发解决方案 REGN5093-M114 靶向MET两个不同表位的双抗ADC抗体偶 ...
REGN5093- M114是靶向MET两个不同表位的双抗ADC,该抗体为1+1非对称型双特异抗体,通过M114 linker将抗体与毒素M24(美登素衍生物)连接。 REGN5093-M114 作用机制 双表位结合与 MET 受体阻断:REGN5093-M114 同时结合 MET 的两个不同表位,有效 阻断 HGF 与 MET 的结合,从而防止 ...
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