PHF8 (KDM7B) is a human non-heme 2-oxoglutarate (2OG) JmjC domain oxygenase that catalyzes the demethylation of the di/mono-Nε-methylated K9 residue of histone H3. Altered PHF8 activity is linked to ...

Generally, proteins in the TCA cycle or closely interacting with the TCA cycle are more readily accessible to succinyl-CoA and to be succinylated (76, 77). Upon succinate feeding, increased protein ...

Abstract—3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) significantly reduce cardiovascular mortality associated with hypercholesterolemia. There is evidence that ...

Catechol-Fe3+ coordinated micelles show the potential for achieving on-demand drug delivery and magnetic resonance imaging in a single nanoplatform. Herein, we developed bioinspired coordination-cross ...

Mallilin, meanwhile, underscored his extensive government experience, including stints at the Department of Justice, National Telecommunications Commission, and now COA. “It has been my honor to be ...

MANILA, Philippines — A Commission on Appointments panel endorsed for plenary approval the nominees to the Civil Service Commission (CSC) and the Commission on Audit (COA) on Wednesday.. Sen. Cynthia ...

“There is a combination of proactive engagements to reassert Brazilian identity and its role in international affairs … and reinserting Brazil in global conversations,” explains Laura Trajber Waisbich ...

科学家们揭示，琥珀酸会选择性抑制2-酮戊二酸脱氢酶复合体（OGDHc）的活性，这个酶本是合成琥珀酰辅酶A（succinyl-CoA）的关键。 当OGDHc罢工时，调节性T细胞（T reg ）中的核心转录因子FOXP3就失去了保护伞——其赖氨酸位点无法获得琥珀酰化修饰，转而暴露在泛素化系统的攻击下，最终导致FOXP3蛋白 ...

BAR HARBOR — College of the Atlantic has announced the slate of speakers for its Summer Institute: Path Breaking.

Abstention rates ran high in this electoral round, with the Mexican electoral agency’s preliminary turnout estimation running from 12.6 to 13.3 percent. For comparison, turnout in last year’s ...