J Control Release：携带sirna的新型纳米药物有望治疗HIV感染. 研究开发出一种新型纳米药物，这种药物含有称为小干扰 RNA的遗传物质，以便可以利用基因 ...

Here we developed an analytical platform based on a combination of quantitative light and electron microscopy (EM) to dissect the mechanisms of LNP-mediated siRNA delivery with high resolution.

The overall result from all the discoveries is a mechanism for siRNA administration that starts with the bonding of siRNAs to particular fatty acids. This combination is linked to lipophilic ...

文章报道了新型肝脏血管紧张素原靶向siRNA候选药物的临床前开发过程——经生物信息学筛选、化学修饰优化及结合肝脏靶向配体，成功开发出了数 ...

RNA interference, a natural mechanism that inhibits the gene expression of individual genes in eukaryotic cells, is a major topic in modern biology. However, their potential was usable to only a ...

Current efforts are addressed towards understanding the role of proteins and associated RNAs in mechanisms underlying piRNA biogenesis and transposon suppression. Skip to ... Recognition of siRNA by a ...

Thus, in a nutshell, the Tuschl I patent describes RNAi roughly depicting the siRNA mechanism. In contrast, the Tuschl II patent specifically describes the dsRNA molecules of precise size with the ...

China has issued a notification of patent grant to bioAffinity for its novel method of using siRNAs to selectively kill ...

Ago2 and hAgo 2 are the PPD proteins involved in siRNA-mediated silencing in nematodes (C. elegans), arthropoda, and chordata. These proteins are efficient in performing siRNA-mediated m-RNA cleavage.

Across two newly published studies the scientists remarkably homed in on the exact nucleotide code underlying this mechanism and believe it may lead to an entirely novel kind of cancer treatment.

today announced the presentation of preclinical data that demonstrate a mechanism of uptake and trafficking of ligand-siRNA conjugates using megalin receptors to achieve targeted gene knockdown in ...