Mechanism For The In-vivo Transport Of SiRNA Date: September 21, 2007 Source: Swiss Federal Institute of Technology Summary: RNA interference, a natural mechanism that inhibits the gene expression ...

China has issued a notification of patent grant to bioAffinity for its novel method of using siRNAs to selectively kill ...

Thus, in a nutshell, the Tuschl I patent describes RNAi roughly depicting the siRNA mechanism. In contrast, the Tuschl II patent specifically describes the dsRNA molecules of precise size with the ...

A model for the mechanism of RNAi. ... This could be accomplished by RISC-mediated delivery of an RdRP or by incorporation of the siRNA into a distinct, RdRP-containing complex.

Across two newly published studies the scientists remarkably homed in on the exact nucleotide code underlying this mechanism and believe it may lead to an entirely novel kind of cancer treatment.

As multiple companies vie to expand on Alnylam’s success in commercializing RNAi therapeutics, the pioneering company has set a goal of targeting small interfering RNA to any tissue by 2030.

Just when scientists thought they had figured out the fundamental mechanisms through which gene expression is regulated, studies of the nematode Caenorhabditis elegans 1 revealed the existence of ...

Two siRNA firms launch Judo ... (RNAi) as a drug mechanism; in 2018, Alnylam became the first company to have an RNAi drug approved by the US Food and Drug Administration.

Megalin ligand-siRNA conjugates led to significant gene knock-down across multiple targets and was durable for up to 40 days in mice. Judo Bio’s Kidney Week poster presentation is available here ...

RNA interference, a natural mechanism that inhibits the gene expression of individual genes in eukaryotic cells, is a major topic in modern biology. However, their potential was usable to only a ...

Preclinical data show intracellular uptake of a ligand-siRNA conjugate in vitro using megalin, an endogenous, endocytic recycling receptor on proximal tubular cells of the kidney Megalin-mediated ...