该研究首次阐明SCU通过AP-1通路改善肥胖相关肾纤维化的分子机制，为开发靶向AP-1的天然药物提供了重要依据。值得注意的是，SCU在25-100 mg/kg剂量范围内均显示显著效果且无剂量依赖性，提示其临床应用可能具有较宽的安全窗。未来研究需进一步解析SCU直接作用靶点，并探索其在其他器官纤维化中的潜在价值。

推荐 为应对透明细胞肾细胞癌(ccRCC)化疗耐药难题，来自国内的研究团队通过整合网络药理学、TCGA-KIRC和GSE53757数据库及单细胞RNA测序(GSE222703)分析，发现Scutellarin可通过调控TYMS、CDCA2等26个核心基因影响氧化应激和细胞周期通路。其中TYMS与CDCA2高表达提示预后良好 ...

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. Studies have demonstrated that Scu exerts a beneficial effect ...

This study advances our understanding of WRKY-mediated regulation of secondary metabolism and offers promising avenues for breeding E. breviscapus cultivars with enhanced scutellarin content. The ...

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Scutellaria baicalensis (SbE) is a commonly used Chinese herb medicine and grape seed proanthocyanidins is a popular herbal supplement in the United States. Both herbs have been shown to possess ...

1 Clinical Medicine, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China 2 Department of Pathogen Biology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, ...

College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P. R. China Correspondence to: Dr. Wei Xu, College of Pharmacy, Fujian ...