In each hippocampus’s CA3 area, humans have about 1.7 million nerve cells called pyramidal cells. This subregion is thought to be the most internally connected part of the brain in mammals.

This forebrain region, located in the medial temporal lobe, has been under close scrutiny for decades, but the discovery of a particular class of cells in the early ‘70s by John O’Keefe shed new light ...

This finding will be invaluable for developing better models for the processing going on in the hippocampus. More information ...

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Example cells shown in panel (E), (G) and (I) are indicated by colored circles ... In vivo two-photon [Ca 2+] imaging Two-photon [Ca 2+] imaging of CA1PCs was performed in vivo in the CA1 region of ...

and although this is impaired relatively early in AD few studies have examined the effects of AD pathology on place cell firing. An in-depth characterisation of hippocampal pyramidal cell activity was ...