Learn more about eLife assessments Sleep disturbances are associated with poor long-term memory (LTM) formation, yet the underlying cell types and neural circuits involved have not been fully decoded.

研究结论和讨论部分指出，该研究揭示了一种由致癌 KRAS 诱导的非经典自噬 RINCAA 的调控机制，明确了 P38-ULK1-PI4KB 轴在其中的关键作用。这一发现不仅丰富了人们对自噬在不同疾病状态下调控机制的理解，更为 RAS 突变癌症的治疗提供了新的潜在靶点和治疗策略。PI4KB 在 S256 和 T263 位点的磷酸化有望成为治疗 RAS ...

C Immunofluorescent staining of GFP (green) and flag (red) from dissociated rat hippocampal neurons expressing Rab5-GFP and β-CTF-flag. D Quantitation of average Rab5+ puncta size of neurons ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Stimulator of interferon genes (STING) is ...

These tears either evaporate or drain away via tiny holes, known as puncta, in the inner corner of the eye. They travel through to the tear sac and then into the nose. 'Crying' is when we produce ...