In contrast, renal medullary total prostanoids significantly decreased in mice pretreated with either COX2 or COX1 inhibitor, supporting a major role for COX2 in renal medullary but not cortical PG ...

PGs and thromboxane A 2 (TXA 2), collectively termed prostanoids, are formed when arachidonic acid (AA), a 20-carbon unsaturated fatty acid, is released from the plasma membrane by phospholipases and ...

Activated monocytes and macrophages contribute to inflammation by releasing a large number of proinflammatory mediators including cytokines such as TNF-α, IL-1β and IL-6; eicosanoids such as ...

Each year, clinical upper gastrointestinal events occur in 2 to 4 percent of patients who are taking nonselective nonsteroidal antiinflammatory drugs (NSAIDs). We assessed whether rofecoxib, a ...

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dCentre for Human & Applied Physiological Sciences, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK eWellcome-Wolfson Institute for ...

The aim was to update the 2009 European League against Rheumatism (EULAR) recommendations for the treatment of systemic sclerosis (SSc), with attention to new therapeutic questions. Update of the ...

ABSTRACT: Sepsis-related haemostatic disorders, especially disseminated intravascular coagulation (DIC), substantially impact morbidity and mortality; nevertheless, early diagnosis is difficult due to ...

Table 1. Suggested strategies for analgesic/anti-inflammatory treatment and cardiovascular prevention among patients with inflammatory disease and different levels of risk of vascular events ...

Meloxicam is an enolcarboxamide with preferential COX-2 inhibitory activity. In vitro studies with human tissues have confirmed the high affinity of meloxicam for COX-2, whereas COX-1 was ...