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生物通
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新型非酯类衍生物揭示阿曲酸在前列腺癌治疗中的新机制
传统观念认为,酯类化合物常被视为前药(prodrug),在细胞内通过水解转化为具有生物活性的药物。但阿曲酸(atraric acid,AA)作为一种含有酯基的天然化合物,虽已被证实是有效的 AR 拮抗剂,能抑制前列腺癌细胞生长并诱导细胞衰老,可它究竟是不是前药 ...
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