University of Pennsylvania researchers have discovered a right-handed, antiparallel double-helix inside influenza ...

Using a combination of molecular biology, biochemical, high-resolution fluorescence and interferometric light-scattering (iSCAT) techniques, we demonstrate that the lipid CL activates backfolded ...

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6a). Figure 6: Nucleotide-dependent processive stepping of myosin V along an actin filament. A diverse array of biophysical and biochemical approaches have lent strong support for the swinging ...

the authors show that five interacting ciliary tip proteins collectively form cork-like structures at microtubule tips and make microtubule growth very slow and processive. Cytokinetic-based rings ...

These results indicate that there is a trade-off between processivity and hydrolytic velocity among processive cellulases. You may have access to this article through your institution. Your ...

季节性流感每年导致290000-650000例死亡。现有疫苗和大多数抗病毒药物靶向病毒表面蛋白，但这些蛋白每个流行季都会发生快速变异，导致保护效果减弱。而流感病毒核心分子机器——核蛋白（NP）和RNA聚合酶的结构特征尚未解析，阻碍了广谱药物的研发。

Subsequent dephosphorylation at the ciliary base then activates OSM-3, enabling its processive movement required for intraflagellar transport. (A) Microtubule stimulated ATPase activity of WT OSM-3 ...

It is well established that cellulose synthesis in higher plants requires three different but related cellulose synthase (CESA) isoforms. Here the authors provide convincing biochemical and cryo ...

流感病毒 RNP 复合物是潜在广谱抗病毒靶点，但其组装及作用机制缺乏高分辨率结构解析。研究人员结合冷冻电镜单颗粒分析与冷冻电子断层扫描技术，揭示 RNP 右手反平行双螺旋结构及聚合酶沿 RNA 模板滑动合成机制，并筛选出潜在抑制剂，为抗流感药物开发 ...

1 Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, China 2 Key Laboratory of Animal Nutrition and Feed Science of Yunnan Province, Yunnan Agricultural University, ...