Using a combination of molecular biology, biochemical, high-resolution fluorescence and interferometric light-scattering (iSCAT) techniques, we demonstrate that the lipid CL activates backfolded ...

Figure 1: Structure and motility models of KIF5 and KIF1A. The kinesin motor domain is composed of a single globular catalytic core and a short strand 'neck linker'. The catalytic core contains ...

DNA (deoxyribonucleic acid) is the nucleic acid polymer that forms the genetic code for a cell or virus. Most DNA molecules consist of two polymers (double-stranded) of four nucleotides that each ...

季节性流感每年导致290000-650000例死亡。现有疫苗和大多数抗病毒药物靶向病毒表面蛋白，但这些蛋白每个流行季都会发生快速变异，导致保护效果减弱。而流感病毒核心分子机器——核蛋白（NP）和RNA聚合酶的结构特征尚未解析，阻碍了广谱药物的研发。

Department of Biomaterial Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan ...

Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, U.K. Kavli Institute of Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, Oxford OX1 ...