Through biophysical experiments and the analysis of conserved amino acids, we identify several motifs that underpin the basis of SteE’s kinase reprogramming activity, allowing GSK3, which is a ...

“In contrast to currently available MEK inhibitors, avutometinib blocks both MEK kinase activity and the ability of RAF to phosphorylate MEK,” Verastem said in a release. “This unique ...

School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, P. R. China Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems, Guangdong ...

1 Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, China 2 Department of Health Management Center, The Affiliated Hospital of Qingdao University, Qingdao, China ...

Although our phosphorylation assays utilized recombinant NEKL-3 due to technical constraints that we could not generate recombinant NEKL-4 with activity, it remains possible that NEKL-4, akin to ...