β-S-ARCA(D1)-capped RNA has a longer physical half-life in immature DCs Our findings suggested that the superior protein yield from RNA species equipped with phosphorothioate cap analogs in human ...

DNA phosphorothioate modification is a distinctive epigenetic alteration in which a non‐bridging oxygen atom within the DNA sugar-phosphate backbone is replaced by sulphur. This covalent change ...

近日来自上海交通大学生命学院的研究人员在DNA骨架硫修饰科学领域又取得新进展，揭示了DNA抗氧化损伤的新机制。相关论文“Phosphorothioate DNA as an antioxidant in bacteria”发表在公布在国际知名分子生物学刊物《Nucleic Acids Research》上。 生物通报道 近日来自上海 ...

Miravirsen is a locked nucleic acid–modified DNA phosphorothioate antisense oligonucleotide that sequesters mature miR-122 in a highly stable heteroduplex, thereby inhibiting its function.

ODAGal4 prominently improves stability of RNAs with phosphorothioate linkages. This improvement in siRNA stability is superior to that observed for other chemical modifications (e.g., 2'-O-methyl ...

To provide a potential approach, the research groups of Weihong Tan and Xue-Qiang Wang at the Hangzhou Institute of Medicine used phosphorothioate backbone modification to enhance the recognition ...

However, the molecular mechanisms of plant fertilization remain largely unknown. We report a transient inhibition of gene function using phosphorothioate antisense oligodeoxynucleotides (AS-ODNs) ...