Here, we use a G-quadruplex (thrombin-binding aptamer) and stem/loop structure (dehydroepiandrosterone sulfate binding aptamer) as model cases to show for the first time that the stereochemistry of ...

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Here, the authors report a one-step method for selectively attaching photocages onto phosphorothioate linkages of antisense oligonucleotides that can knockdown cell-free protein synthesis using light.

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The gene gp48 from the mycobacteriophage ...

Originally identified as moderate biological modifiers, microRNAs have recently emerged as powerful regulators of diverse cellular processes with especially important roles in disease and tissue ...

BEIJING, May 15, 2025 /PRNewswire/ -- Tsingke Biotech proudly participated in the AACR Annual Meeting 2025, held this April in Chicago, USA.As one of the world's premier events in oncology research, ...

This is an important study that establishes how anti-sense oligonucleotides (ASOs) degrading a specific target protein called EMC10 can rescue neuronal function in models of chromosome 22.11.2 ...