Perturb-FISH推进了细胞内回路的功能基因组学研究，并为细胞间回路的遗传学研究提供了丰富的分子细节。 该方法不仅能够揭示细胞内扰动的分子机制，还能解析细胞间相互作用的复杂网络，为理解细胞在组织尺度上的功能提供了新的视角。

Recently, scientists have been able to explore gene circuitry in individual cells using methods that suppress particular ...

The researchers next showed that when macrophages were exposed to inflammatory signals, their activity changed alongside ...

Broad研究所和波士顿大学的研究人员开发出一种名为 Perturb-FISH 的新技术。该技术巧妙地结合了成像空间转录组学（iST）和 CRISPR 扰动的读数，犹如给细胞研究安装了 “透视镜”，能在单细胞水平解析分子和功能状态。

最近，科学家们通过抑制特定基因并测量其对其他基因表达的影响，能够在单个细胞中探索基因回路。然而，这些方法未能捕捉到空间信息，例如细胞之间的相互影响，而这些信息对于理解细胞或基因在健康和疾病中的作用至关重要。

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Interstellar material has been discovered in our solar system, but researchers continue to hunt for where it came from and ...