为探究阿尔茨海默病（AD）患者抑郁的临床特征及相关机制，首都医科大学附属北京天坛医院研究人员开展研究，发现脑脊液中 orexin A 水平升高可介导脑萎缩与抑郁的关联，对预测 AD 患者抑郁有重要意义。 研究背景 在神经医学领域，阿尔茨海默病（Alzheimer’s ...

2025年3月12日周三，Alkermes Plc（NASDAQ: ALKS）在2025年Leerink全球医疗大会上发表演讲，重点介绍了其Orexin管线和强劲商业产品的战略重点。公司在竞争压力下强调了其神经科学领域的重点和增长战略，同时阐述了机遇与挑战。

该公司的分析表明，Alkermes的股价目前已经考虑了即期挑战，同时也计入了其开发中治疗药物的潜在收入。RBC Capital Markets的立场表明，他们正在密切关注更多数据，以进一步评估该药物在竞争市场中的前景以及公司的整体财务健康状况。 InvestingPro ...

Daridorexant, Idorsia’s dual orexin receptor antagonist, shows consistent efficacy across both insomnia- and nocturia-related endpoints in a placebo-controlled study in patients with chronic insomnia ...

BofA raised the firm’s price target on Alkermes (ALKS) to $35 from $34 and keeps a Neutral rating on the shares. The firm’s higher target reflects a higher P/E multiple given recent moves in peer ...

In 1998, we purified a novel neuropeptide orexin and showed that this peptide plays pivotal roles in the regulation of appetite and sleep. In this ERATO project, we showed that the administration of ...

More information: Insung Park et al, Orexin receptor antagonist increases fat oxidation and suppresses protein catabolism during sleep in humans, iScience (2024). DOI: 10.1016/j.isci.2024.110212 ...

Previous studies indicated that among other neurons, those in the hypothalamus that secrete the neuropeptide orexin simultaneously control both food intake and energy expenditure. 3 This prompted ...

A follow-up study in 2018 revealed that the DEC2 gene mutation affects levels of orexin, a hormone that regulates wakefulness. Normally, the DEC2 gene shuts off orexin production in the evening ...

The two major types of narcolepsy are: Narcolepsy type 1. People with type 1 narcolepsy have low levels of orexin (hypocretin), a brain chemical that regulates wakefulness. Damage to the brain ...