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基于生物信息学的布鲁氏菌多表位融合蛋白制备及其在人布鲁氏菌病 ...
为解决布鲁氏菌病诊断中传统抗原(如LPS和Rose Bengal抗原)存在的交叉反应性问题,研究人员通过生物信息学方法预测布鲁氏菌5种抗原蛋白(Erythritol kinase、NDK等)的B细胞线性表位,构建多表位融合蛋白,并建立间接ELISA(iELISA)检测体系。结果显示,该融合 ...
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