Based on several lines of interesting data, the authors conclude that FMRP, though associated with stalled ribosomes, does not determine the position on the mRNAs at which ribosomes stall. Although ...

As an indispensable molecular machine universal in all living organisms, the ribosome has been selected by evolution to be the natural target of many antibiotics and small-molecule inhibitors.

Monosomes and polysomes (hereafter collectively referred to as “polysomes” for simplicity), which consist of mRNAs loaded with one or more translating ribosomes, constitute a sizeable and abundant ...

Monosomes were pelleted by ultracentrifugation in a 34% (wt/vol) sucrose cushion at 70,000 rpm for 3 h (TLA 120.2, Beckman Coulter), and RNA fragments were extracted twice with acid phenol, once with ...