The pri-miR-129 sequence was amplified from normal human genomic DNA and cloned into the pWPXL lentiviral vector (a generous gift from Dr. Didier Trono) to generate Lenti-miR-129-5p. pWPXL-SLC2A3 was ...

Find more information on the Altmetric Attention Score and how the score is calculated. The use of cancer-relevant microRNA molecules as endogenous drug release stimuli is promising for personalized ...

The Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China ...

MicroRNAs (miRNAs) are small non-coding RNAs, 18–23 nucleotides long, which act as post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the pathogenesis of many common ...

推荐 为探明多层菊形团胚胎性肿瘤（ETMR）的分子机制与治疗策略，研究人员对 11 例患者样本进行单细胞转录组和空间成像分析。发现其存在干细胞样与神经元样细胞层级，揭示 C19MC 调控干性、FGFR/Notch 通路驱动肿瘤。为 ETMR 靶向治疗提供关键依据。 论文解读 ...

As developers look to harness the power of AI in their applications, one of the most exciting advancements is the ability to enrich existing databases with semantic understanding through vector search ...

1 Italian Institute for Genomic Medicine (IIGM), c/o IRCCS Candiolo, Torino, Italy Objectives MicroRNA (miRNA) profiles have been evaluated in several biospecimens in relation to common diseases for ...

本研究揭示了翻译过程对靶向介导的microRNA降解(TDMD)的关键调控作用。研究人员通过构建人工报告系统，发现位于编码区(CDS)的TDMD触发序列因核糖体干扰而效率低下，而翻译抑制剂处理可显著增强其降解miRNA的能力。该发现解释了自然界中TDMD触发序列为何多位于 ...

In “Let-7a-regulated translational readthrough of mammalian AGO1 generates a microRNA pathway inhibitor” by Singh et al, 2019, and “Transcript-specific induction of stop codon readthrough using a ...