Figure 1: Using microRNA target sites to target transgene ... or a versatile system for studying miRNA function. However, despite the promise of the early studies, we must recognize that our ...

A multitude of microRNA tumour suppressors Since these early findings, other miRNAs that function as tumour suppressors have been discovered (Table 1). Table 1 MicroRNAs that function as oncogenes ...

Researchers at the University of Exeter Medical School have uncovered a protective role for the microRNA miR-483-5p in the ...

To investigate how microRNAs are involved in neuron differentiation, the team developed new tools that temporarily turn off microRNA function during specific developmental windows. They found that ...

Differences in gene regulation across development drive cell diversity and the emergence of specialized cellular functions. By the early 1990s ... Nearly a decade after the discovery of the first ...

The origin of their recognition comes from a pair of studies published in the journal Cell way back in 1993, which demonstrated for the first time that microRNA ... of neural function and disease ...

The microRNA is located within a short segment ... this approach to deliver genes at a level that would restore normal function and reverse signs of disease, either in cultured cells or animal ...

Our understanding of RNA diversity and complexity is rapidly expanding. Particularly microRNAs have emerged as informative biomarkers of cell status and function. Sensitive, specific and unbiased ...

Fibrosis, driven by abnormal extracellular matrix (ECM) accumulation, disrupts normal adipose tissue function and contributes to broader organ dysfunction. The review explores how miRNAs act as ...

American molecular biologist Victor Ambros, co-discoverer of microRNA and joint recipient of the 2024 Nobel Prize in Physiology or Medicine, has received an honorary doctorate from the Silesian ...