Interestingly, patients with classical reflux symptoms who tested off PPI had significantly higher mean DCI than those with classical reflux symptoms on PPI. We conclude that stopping PPIs for 7 days ...

Of the symptomatic cohort, 29 patients underwent repeat HRiM assessment following BT injection into the UES. Baseline manometric findings revealed significantly reduced esophageal contractility in ...

Achalasia, a chronic oesophageal motility disorder, is defined by impaired lower oesophageal sphincter relaxation and absent peristalsis, leading to symptoms such as dysphagia and regurgitation.

Eosinophilic esophagitis (EoE) is a chronic esophageal inflammatory disease of undetermined pathophysiology that results in dense mucosal eosinophilia and esophageal dysfunction. In childhood ...

A new class of metabolite, with a pyrrole-like structure, has been demonstrated in the tissues of animals poisoned by pyrrolizidine alkaloids. There is some correlation between the degree of ...

Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder that significantly affects populations in both developing and developed countries. Due to both intrinsic pathology and ...

Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA Correspondence to Dr Megan Coylewright, Division of Cardiovascular Diseases, Department of ...