An elegant screening strategy unveils a molecular actor that connects widespread changes in mRNA processing with a nutrient-sensing protein modification.

The major challenge is to define the functions of these mRNA export factors. A further puzzle is that a mammalian homologue of Yra1, ALY, has been shown to bind some transcription factors ...

Specifically, we investigate how 3′UTRs regulate protein functions in a manner that is independent of protein abundance. We found that inclusion or exclusion of the 3′UTR of an mRNA that encodes a ...

The underlying goal of our research is to uncover molecular mechanisms governing mammalian gene expression. In particular we are interested in understanding the regulation of mRNA transcription and ...

K nowing the location of a gene within intact tissue or a single cell allows scientists to unlock unknown cellular functions.

This manuscript characterizes a mutated clone of RNA polymerase I in yeast, referred to as SuperPol, to understand the mechanisms of RNA polymerase I elongation and termination. The authors present ...

When developing mRNA therapeutics, capping technology plays a crucial role in determining the stability, translation efficiency and immunogenicity of synthetic mRNAs. Advancements in ...

How does a COVID-19 mRNA vaccine work? COVID vaccines are now available. Some of the COVID-19 vaccines are mRNA vaccines, but what does this mean? mRNA vaccines are different from traditional ...