Despite past failures, Denali's extensive pipeline and solid financial runway make it a compelling buy at current low stock ...

This paper reports important findings on giant organelle complexes containing endosomes and lysosomes (termed endosomal-lysosomal organelles form assembly structures [ELYSAs]) present in mouse oocytes ...

Gaucher disease (GD) is an inherited disorder caused by recessive mutations in the GBA1 gene that encodes the lysosomal enzyme β-glucocerebrosidase (β-GC). β-GC hydrolyzes glucosylceramide (GluCer) ...

As dysfunctional lysosomal activity is linked to inflammation, Harvey et al. focus on nuclear receptor coactivator 7 (NCOA7), which binds to V-ATPases to modulate lysosomal function and is up ...

This study reports that activation of TFEB promotes lysosomal exocytosis and clearance of cholesterol from lysosomes, the strength of evidence for which is convincing with appropriate and validated ...

近日，SCIENCE CHINA Life Sciences 在线发表中国科学院昆明植物研究所郝小江研究员团队题为“Isowalsuranolide targets TrxR1/2 and triggers lysosomal biogenesis ...

Charles Schwab Investment Management Inc. grew its holdings in shares of Denali Therapeutics Inc. (NASDAQ:DNLI – Free Report) ...

It’s been just six months since Zevra Therapeutics scored an FD | Niemann-Pick disease type C therapy Miplyffa became ...

A new study led by Profs. Fan Kelong and Yan Xiyun from the Institute of Biophysics of the Chinese Academy of Sciences ...

Laboratory of Computer-Aided Molecular Design, Division of Medicinal Chemistry, Otto-Loewi Research Center, Medical University of Graz, Neue Stiftingtalstr. 6/III, A-8010 Graz, Austria ...