Scleroderma affects the body’s immune system which attacks its own tissues causing hardening of the skin, in some cases like ...

Other vasodilators are medicines that you inhale, like iloprost (Ventavis) and treprostinil (Tyvaso). They go straight to your lungs and can quickly relieve shortness of breath. To take them ...

The aim was to update the 2009 European League against Rheumatism (EULAR) recommendations for the treatment of systemic sclerosis (SSc), with attention to new therapeutic questions. Update of the ...

理解吸入药物的临床药代动力学（PK）特性对剂量优化和药物开发至关重要。本文系统分析了关键吸入PH药物（包括获批及在研药物，如前列环素类[epoprostenol、iloprost、treprostinil]、磷酸二酯酶-5抑制剂[vardenafil]、酪氨酸激酶抑制剂[imatinib、seralutinib]、其他候选药物 ...

Highly potent but poorly water-soluble drug (PWSD) candidates are common outcomes of contemporary drug discovery programmes. These lipophilic compounds often exhibit poor systemic exposure ...

Patients with peripheral artery disease (PAD) are at heightened risk of both systemic cardiovascular adverse events, as well as limb-related morbidity. The optimal management of patients with PAD ...

The diverse causes of right-sided heart failure (RHF) include, among others, primary cardiomyopathies with right ventricular (RV) involvement, RV ischemia and infarction, volume loading caused by ...

Treatment of children and adults with pulmonary hypertension (PH) with or without cardiac dysfunction has improved in the last two decades. The so-called pulmonary arterial hypertension (PAH)-specific ...

Contributed by Maria I. New, June 3, 2017 (sent for review October 28, 2016; reviewed by Wafik S. El-Deiry, Christopher Huang, and H. Michael Shepard) ...