28 There is a direct interaction of the hydroxamic moiety of SAHA with the active zinc site of the catalytic pocket of HDAC (Figure 1). This interaction appears to be a prerequisite for optimal ...

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The enzymatically catalysed exchange can be easily detected and assayed with hydroxylamine as the acceptor amine, since the γ-glutamo and β-asparto hydroxamic acids produced give the colour ...

§ Chemical Biology Program, Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, United States ∥ Center for Human Genetic Research, Massachusetts General Hospital, ...

The global hydroxylamine sulfate industry size is expected to grow at a steady CAGR range of 3% to 5.6% during the forecast period of 2022 to 2032. The growing applications of hydroxylamine sulfate in ...

Baseline physiological function of the mammalian heart is under the constant threat of environmental or intrinsic pathological insults. Cardiomyocyte proteins are thus subject to unremitting pressure ...

When Ring C is replaced by hydroxyl (OH) as seen in scaffold B-3 (SH8, SH16, SH24, SH32, SH40), activity was diminished, notwithstanding the retention of the zinc binding motif which is now ...

脲酶（Urease）作为某些病原体的毒力因子，会引发多种疾病。研究人员设计、合成一系列含哌嗪 / 哌啶片段的氨磺酰异羟肟酸并评估其作为脲酶抑制剂的效果。结果显示这些化合物抑制活性强，有望开发为新药。 在人体健康的复杂版图中，微生物与疾病的关系 ...