28 There is a direct interaction of the hydroxamic moiety of SAHA with the active zinc site of the catalytic pocket of HDAC (Figure 1). This interaction appears to be a prerequisite for optimal ...

Reactive oxygen species (ROS) are involved in physiological cellular processes including differentiation, proliferation, and apoptosis by acting as signaling molecules or regulators of transcription ...

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China Key Laboratory of Marine Drugs, Chinese Ministry of ...