Understanding the molecular mechanisms of insulin resistance remains a major medical challenge of the twenty-first century. Over the last half-century, many hypotheses have been proposed to ...

Innovations are focusing on novel targets not yet fully explored by other treatment modalities, such as hexokinase 2 (HK2), neurotensin receptor 1 (NTSR1), and gastrin-releasing peptide receptor 1 ...

Cheng et al. identify a mitochondrial complex IV (CIV) deficiency in the brains of patients with sporadic amyotrophic lateral sclerosis (ALS). They demonstrate that defects in mitochondrial CIV ...