Here authors discover that inhibition of guanine nucleotide biosynthesis leads to myeloid differentiation and sensitization to menin inhibitors in leukemia stem cells of MLLr leukemia. Zhu and ...

Neurologists have grappled with a cluster of amyotrophic lateral sclerosis cases in France, where a fondness for a toxic wild ...

This article explores 6-base genome sequencing and how it is empowering researchers to expand their studies to include both ...

目前，虽然基因编辑疗法为 DMD 的治疗带来了一丝希望，但临床应用的道路上仍布满荆棘，比如难以确定临床疗效、无法有效控制潜在的脱靶效应等。而糖皮质激素（如地夫可特、泼尼松）虽能延缓疾病进展，却也伴随着肥胖、行为改变、身材矮小和骨质减少等诸多副作用，就像 “饮鸩止渴”，让患者陷入两难境地。因此，寻找更安全有效的治疗方法，成为了医学领域亟待攻克的难题。