We show that colorectal cancer (CRC) with loss-of-function mutation in the APC tumor suppressor depends on an oncogenic translation program regulated by the ability to sense phosphorylated eIF2α ...

It is crucial to investigate the correlation between aging and the proteins eIF2β and eIF2α. Thank you so much for your review and comments. We included analyses of protein levels of eIF2α, eIF2β, and ...

A small study suggests that people in their 40s and 60s undergo sizable physiological changes that may be connected to age-related illnesses. When you purchase through links on our site, we may ...

This study aimed to investigate the role of the ISR in myocardial ischemia/reperfusion (I/R). We show that the PERK (PKR-like endoplasmic reticulum resident kinase)/eIF2α (α subunit of eukaryotic ...

Here, we reviewed the antecedents supporting PKR and the consequences of its activation as a key player in physiological conditions and its contribution in the neurodegenerative process involved in ...

Furthermore, the Ssd1-mediated reduction in protein synthesis during aging enabled optimization of the normal lifespan, because Ssd1 loss shortened lifespan while Ssd1 overexpression extended lifespan ...

Distinct cellular stresses converge on the translation initiation factor, eukaryotic initiation factor 2α (eIF2α) to modulate the rate of protein synthesis. Increased phosphorylation of eIF2α has been ...