Department of Medical Genetics and Microbiology and Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8 Article Views ...

† Department of Molecular Life Science and Institute of Natural Sciences, Yeungnam University, Gyongsan 712-749, Korea ‡ Department of Food Science and Nutrition, Kyungpook National University, Daegu ...

此外，分子对接显示，该类化合物与二氢蝶酸合酶（Dihydropteroate synthase）、分选酶 A（Sortase A）、LasR 和青霉素结合蛋白（penicillin-binding protein）口袋的活性位点通过不同类型的相互作用具有较低的结合能，表明这些化合物可抑制相关酶并产生有前景的抗微生物 ...

本研究针对抗生素耐药性日益严峻的全球健康挑战，设计并合成了一系列靶向细菌二氢蝶酸合酶(DHPS)的新型噻吩并[2,3-d]嘧啶杂合化合物。通过生物电子等排体替换和间隔基修饰策略，研究人员发现化合物5b、14a和14b对金黄色葡萄球菌(S. aureus)表现出显著抗菌活性 ...

We describe a case series of 28 patients older than 18 years old identified as presenting a bloodstream and/or sterile site acquired infection caused by ColRKP at the Hospital das Clinicas, a 1,000 ...