Due to low solubility, many ECM proteins have been underrepresented in previous proteomic datasets. Using an optimized three-step decellularization and ECM extraction method involving chaotrope ...

Cardiovascular defects, injuries, and degenerative diseases often require surgical intervention and the use of implantable replacement material and conduits. Traditional vascular grafts made of ...

In this study, polydimethylsiloxane (PDMS)-based anisotropic topographies (wrinkles) with various topography dimensions were prepared and subsequently combined with native ECMs produced by human ...

Geoffrey S. Ginsburg ( [email protected]) is director of the Duke Center for Applied Genomics and Precision Medicine, Duke University, in Durham, North Carolina. Kathryn A. Phillips is a ...

Meniscus tears are common knee injuries that have long frustrated patients and doctors due to limited repair options. A new 3D-printed hydrogel made from cow meniscus could transform how ...

Capacity to autonomously respond to external stimuli with some switchable structural shapes/properties/functions is highly desirable in many occasions where either system service environments or ...

In the US, nearly 4,000 people await a heart transplant and more than six million live with heart failure caused by different cardiac conditions. To help address a shortage of life-saving organs, ...

Background—In the Fontan circulation, pulmonary and systemic vascular resistances are in series. The implications of this unique arrangement on infradiaphragmatic venous physiology are poorly ...