Cornification: The process by which epidermal cells produce a hardened, protective layer through protein cross-linking and cellular differentiation. Epidermal Differentiation Complex (EDC): A ...

Objective Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the population but its aetiology, including suspected genetic predisposition, is poorly understood. We report ...

Dermatitis. 2005;16(1):6-21.

Lastly, the granular and terminal clusters expressed genes consistent with differentiation and cornification of keratinocytes (CLIC3, SPRRIB, and FLG2). Altogether, our data revealed a meaningful gene ...

功能富集分析 研究意外发现肺鳞癌中角质化（cornification）和表皮分化通路显著激活，免疫组化验证了角化标志物（involucrin、loricrin）在肿瘤组织的过表达。分子功能层面，神经活性配体-受体相互作用和钙信号通路富集，提示跨膜信号传导在肿瘤发生中的关键 ...

这篇综述深入探讨了鸟类皮肤附属物发育过程中中间丝角蛋白（IFKs）与角质β蛋白（CBPs，原称β-keratins）的协同作用机制。研究通过免疫标记和电镜技术揭示，IFKs与源自表皮分化复合体（EDC）的CBPs通过静电（-S-S-和ε键）与共价键结合，形成羽毛、鳞片、喙和爪 ...