These findings suggest that aberrant expression of ERBB-2 and COX-2 is a common feature of human and rat cholangiocarcinomas and that targeting of both proteins may prove useful as a therapeutic ...

Merck‘s M7824, a bifunctional immunotherapy, just received FDA orphan drug designation for treating biliary tract cancer. This rare gastrointestinal menace includes intrahepatic and extrahepatic ...

Cholangiocarcinomas are malignant tumors that derive from cholangiocytes of small intrahepatic bile ducts or bile ductules (intrahepatic cholangiocarcinoma; ICC), or of large hilar or extrahepatic ...

Efficacy and safety in advanced hepatocellular carcinoma using atezolizumab plus bevacizumab combined with interventional therapy: A retrospective analysis of real-world evidence. This is an ASCO ...

According to the American Cancer Society, more than 40,000 patients are diagnosed with liver or biliary tract cancers each year, with cholangiocarcinomas accounting for around 8,000. Incidence has ...

FGFR Tyrosine Kinase Inhibitors (TKIs) have recently received FDA approval for the treatment of intrahepatic cholangiocarcinomas and urothelial cancers with susceptible FGFR2 or FGFR3 alterations.

Overexpression is more frequently observed in extrahepatic cholangiocarcinomas and gallbladder cancer, for example. "I don't want to imply that we clearly know whether one targeted agent or ...

Very few bile duct cancers (5–10%) are intrahepatic, andthey are also known as intrahepatic cholangiocarcinomas. The different methods for analysis of intrahepatic bile duct tumors under a ...

At present, the diagnosis of LEL-ICC mainly depends on the histopathologic and immunohistochemical examinations. In addition, the prognosis of LEL-ICC was better than classical cholangiocarcinomas. To ...

Distal cholangiocarcinomas are rare, but clinicians can use a variety of imaging to diagnose it. A new case report of a patient with distal cholangiocarcinoma highlights how imaging and ...

Cholangiocarcinomas (CCAs) are a highly aggressive and diverse group of malignancies of the biliary tract that currently account for 15% of all liver cancers and approximately 3% of ...

Cholangiocarcinomas are classified according to their relative anatomical location: intrahepatic, perihilar, and distal extrahepatic. An alternative way of classifying cholangiocarcinomas is to refer ...