A protein called angiopoietin-2 (ANGPT2) can both inhibit and encourage blood vessel changes critical for sepsis, a leading ...

The blood-CSF barrier has been far less studied than the blood-brain barrier. Scientists have detected age-related changes in gene expression in the choroid plexus, and have linked these to increased ...

which recently generated positive phase 2 data in the Tailwind study – along with Boehringer Ingelheim's cathepsin C Inhibitor BI-1291583 (phase 2), Sanofi's anti-IL-33 antibody itepekimab ...

该化合物为线性多肽，N 端修饰邻氨基苯甲酸（Abz）作为荧光供体，C 端连接 2-(2 - 硝基苯基) 乙二胺（EDDnp）作为淬灭基团，形成内淬灭荧光底物。氨基酸序列包含缬氨酸（Val）、丙氨酸（Ala）、天冬氨酸（Asp）、正缬氨酸（Nva）、精氨酸（Arg）和谷氨酰胺（Gln ...

Notably, microglia spatially associated with amyloid plaques exhibited increased expression of TREM2 and ApoE compared to ...

Mechanistically, Mtb Mce3C can bind host cathepsin B (CTSB), a lysosome-derived non-caspase protease that determines cell modalities. This binding inhibits CTSB's protease activity towards BH3 ...

Proteases are enzymes that catalyse hydrolysis of the peptide and isopeptide bonds that join amino acids within proteins (known as proteolysis). Proteases can also remove protein post ...

The complement system is one of the immune system’s oldest defense mechanisms and is historically regarded as a liver-derived and serum-active innate immune system that ‘complements’ cell-mediated and ...

2月26日， 国际学术期刊Neuron在线发表了中国科学院分子细胞科学卓越创新中心（生物化学与细胞生物学研究所）沈义栋研究组联合上海交通大学医学院附属新华医院鄢秀敏团队的最新研究成果 “Macrophage-derived CTSS drives ...