Calcium-activated proteolysis by calpain is a candidate to participate in this form of pathology because it is activated under ischemic conditions and its activation results in the degradation of ...

A new role of calcium in the development of muscles has been reported by two RIKEN biologists. Stress is generally damaging and destructive, but it can sometimes spur productivity and creation.

The two researchers quickly homed in on a calpain known as calpain-5. They found that this enzyme undergoes rapid activation in the early stages of myoblast differentiation—a crucial process in ...

A major problem in people with Parkinson’s disease is calpain, a protein that is highly expressed in their brains and known for being the cause for neuronal degeneration. Even though E2 has been known ...

Such tests are increasingly moving beyond their origins in cutting-edge research and into the laboratory and diagnostic ...

AMX0014, meanwhile, is a calpain-2-targeting antisense drug, in late preclinical development, with an initial clinical trial due to start before year-end. “Our pipeline is supported by ...

六、相关文献 [1] Goll DE, Thompson VF, Li H, Wei W, Cong J. The calpain system. Physiol Rev. 2003 Oct;83(4):731-801. [2] Sorimachi H, Imajoh - Ohmi S, Emori Y, Kawasaki H, Suzuki K. Molecular cloning and ...

FIGURE 1. Primary phase of injury from TBI. The primary phase of injury occurs during impact, leading to disruption of cellular membranes. Increased intracellular calcium levels activates calpain, ...

1 Translational and Clinical Research Institute, Newcastle University, BioMedicine West, Newcastle-upon-Tyne, United Kingdom 2 Endocrine Unit, Royal Victoria Infirmary, Newcastle-upon-Tyne, United ...