Cell adhesion is the process by which cells form contacts with each other or with their substratum through specialized protein complexes. Intercellular adhesion can be mediated by adherens ...

Stroke is the leading cause of serious long-term disability, significantly reducing mobility in almost half of the affected patients aged 65 years and older. There are currently no proven ...

Gottardi, Ph.D. In the current study, Gottardi's team studied a single protein within these intracellular adhesive junctions, called alpha-catenin, which links cadherins—proteins that help cells ...

This study on mouse Ly49 receptors expressed on natural killer (NK) cells shows that Ly49A, in the presence of the corresponding MHC class I allele, can lead to NK cell licensing, thereby providing ...

Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPAR gene expression.

Glioma is the most malignant cancer of the central nervous system. There are various therapies for treating gliomas, but their outcomes are not satisfactory. Therefore, new targets for glioma ...

Keywords: cadherins, epithelial homeostasis, adherens junctions, mechanotransduction, mechanobiology Alpha’s lab is trying to understand how cell-cell adherens junctions support epithelial homeostasis ...