基因表达调控是决定细胞命运的重要因素，通过改变基因的表达模式即可实现对细胞命运的精准调控。比如运用Yamanaka四个转录因子（Oct4, Sox2, Klf4, c-Myc）在体外就可将体细胞成功重编程为诱导多能干细胞。 基因表达调控是决定细胞命运的重要因素，通过改变 ...

排在第一的是今年诺贝尔生理/医学奖得主山中伸弥的代表作，这篇论文中，山中伸弥等人首先用4个干细胞转录因子OCT4、SOX2 ...

Mouse somatic cells can be reprogrammed into pluripotent stem cells by ectopic expression of the reprogramming factors Oct4, Sox2, c-Myc and Klf4, which are highly expressed in embryonic stem (ES ...

Methods: In this study, the expression levels of the embryonic stem cell reprogramming factors Oct4, Nanog, Myc, Sox2, and Klf4 were examined via immunohistochemistry in a panel of 71 benign ...

It is well known that adding a mixture of four reprogramming molecules (Oct4, Sox2, Klf4 and c-Myc) also known as “Yamanaka factors” to cells can reset epigenetic marks to their original patterns.

Lu’s builds his work on the four transcription factors- Oct4, Sox2, Klf4, c-Myc discovered by Shinya Yamanaka. These factors can erase the cell’s epigenetic markers and return these cells to ...

Differential H3K27AC marks were identified at enhancer regions of genes including c-MYC, MED1, OCT-4, NANOG, and SOX2 that can act as super-enhancers (SE), cluster of genes in non-cancerous ...