Here we show that adult mouse neural stem cells express higher endogenous levels of Sox2 and c-Myc than embryonic stem cells, and that exogenous Oct4 together with either Klf4 or c-Myc is ...

Mouse somatic cells can be reprogrammed into pluripotent stem cells by ectopic expression of the reprogramming factors Oct4, Sox2, c-Myc and Klf4, which are highly expressed in embryonic stem (ES ...

Although the technique reliably produces iPSCs, cellular reprogramming with the four Yamanaka factors—Oct4, Sox2, Klf4, and cMyc (collectively ... while a synthetic factor that selectively adopts ...

Lu’s builds his work on the four transcription factors- Oct4, Sox2, Klf4, c-Myc discovered by Shinya Yamanaka. These factors can erase the cell’s epigenetic markers and return these cells to ...

Differential H3K27AC marks were identified at enhancer regions of genes including c-MYC, MED1, OCT-4, NANOG, and SOX2 that can act as super-enhancers (SE), cluster of genes in non-cancerous ...