2025年5月6日，专注于表观遗传重编程的初创企业 NewLimit 宣布完成 1.3 亿美元的 B 轮融资。本轮融资由凯鹏华盈（Kleiner Perkins）领投，Founders Fund、Khosla Ventures、Human ...

本研究揭示了Aurora A（AurA）激酶通过特异性结合c-Myc转录激活域（TAD）并识别其N端磷酸化降解基序（T58/S62）的分子机制。研究 ...

在这里，我们证明人类脐带血细胞的特定子集可以通过称为 Sox2 的多能转录因子的表达转化为神经元细胞。 通过添加另一个称为 c-Myc 的因子，可以进一步增强此过程。 基因表达和电生理学分析表明，转化的细胞获得了以多种神经元标记物表达为特征的独特神经 ...

(C) CCAT1-L regulates MYC expression at the transcriptional level. A crude preparation of nuclei was subjected to nuclear run-on assay under the indicated conditions in HT29 cells.

Viral-mediated Oct4 overexpression induces direct conversion of wildtype mammalian Müller glia to bipolar neurons, and this process is synergistically enhanced by loss of Notch signaling.

随着国际空间站（ISS）的建立，科学家获得了长期微重力研究平台。与此同时，2006年山中伸弥团队通过转录因子OCT4、SOX2、KLF4和c-MYC（即“山中因子”）成功将成体细胞重编程为诱导多能干细胞（iPSCs），解决了胚胎干细胞的伦理困境。2010年后，hiPSCs被广泛应用 ...

Pioneered by Dr. Chidiebere Awah MD, PhD, our CEO and Principal Investigator, UTRxM1-18 targets oncogenic c-MYC by recognizing specific motifs and switching the ribosome machinery from a ...

日本科学家山中伸弥发现，通过短暂激活四种关键转录因子（OCT4、SOX2、KLF4 和 c-MYC，统称 OSKM），可以使老化的人类皮肤细胞部分恢复年轻状态。

This manuscript demonstrates that Oct4 overexpression synergizes with Notch inhibition (Rbpj knockout ... Mouse eye globes were fixed in 4% paraformaldehyde (ElectronMicroscopySciences, #15710) for 4 ...

As described previously (see factors and mechanism of pluripotency), complete reprogramming of somatic cells occurs only when the expression of endogenous genes associated with pluripotency (Oct4, ...

NBC News Senior Congressional reporter Scott Wong previews a key week in the GOP budget reconciliation process and Middle East Institute Paul Salem discusses President Trump's Middle East trip ...