Inhibitors of histone deacetylases (HDACs) have received special attention as novel anticancer agents. Among various types of synthetic inhibitors, benzamides constitute an important class, and one is ...

Bioorthogonal reactions are valuable tools for the selective labeling and imaging of natural products and proteins. Here, we present the reaction between isonitriles and chlorooximes as a ligation ...

Allen Lee; Braden Kuo Disclosures Expert Rev Endocrinol Metab. 2010;5 (5):653-662.

Mechanism of Action Trametinib is a highly selective reversible allosteric inhibitor of MEK1 and MEK2 activity. [5, 6] It is an ATP non-competitive inhibitor that binds MEK adjacent to the ATP ...